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What about penile injections?

Author: keegan segal

Article source: http://www.articlesfactory.com/. Used with author's permission.

The article describes the three medications used for the relief of erectile dysfunction that are delivered by penile injection. Only one, prostaglandin E1, has FDA approval but all three are available for on- or off-label use.

This is a topic that every man approaches with a degree of fear. You mean someone is going to stick a needle into my penis? For the record, they are called intracavernous injections and your physician will give you an auto-injector that works with a simple push-button mechanism. You hold the head of your penis and stretch it along your thigh while sitting upright. You have to make the injection at the base of the penis (or you can ask your partner to do it for you). Although it is an area that is sensitive to pleasure, it does not register too much pain. The sensation is no worse that being flicked with an elastic band. After the injection, you have to apply pressure to the injection site with an alcohol swab for about five minutes (or until the bleeding stops). You should aim for a slightly different point for each injection, rotating the penis a little if necessary. This will reduce the risk of bruising or scarring. The erection usually lasts for about an hour.

 

Hmmm. This needs thought! Why can I not simply pop a Viagra, Cialis or Levitra?

 

Well, no matter how successful they are for most men regardless of age and regardless of the underlying cause of erectile dysfunction (ED), there are limits to the PDE-5 inhibitors. These limits may be physical — the underlying cause of the ED is sufficiently far advanced that Viagra, Cialis or Levitra simply will not work. Or you may already be taking medications for those underlying causes which, for now, make it impossible for you to take one of the PDE-5 inhibitors at an effective dosage.

 

This forces us to discuss a range of alternative treatments. The first for these purposes, is a penile injection.

 

These injections have been available for almost twenty years so we doctors are not experimenting on you. The technology and the medications are well tested and routinely used. The first and the only one with Food and Drug Administration (FDA) approval for use in the treatment of erectile dysfunction is prostaglandin E1, sold as Alprostadil and Prostin VR. It is a naturally occurring chemical released by the smooth muscle cells of the penis when you are sexually stimulated. As such, it has the best success records with the fewest side effects and, if you are resident in the United States, the cost is covered by most prescription plans.

 

It is also available as a small pellet sold under the brand name, Muse, which you insert into the tube through which urine passes from the bladder out of your body. Now this is slightly more complicated than it sounds. You have to use a device which opens up the canal sufficiently to allow the tablet to be inserted inside your penis. This may not be a completely comfortable process either in the insertion or when the penis closes around the pellet. As you will realise, the tablet slowly dissolves and so the pressure on the penis diminishes fairly rapidly. Some men report a slight burning sensation as the medication is absorbed into the penis. There can also be a drop in your blood pressure so you should not be taking any other medication which may have an additive effect. It is also not advisable to consume alcohol before using Muse.

 

Papaverine is a vasodilator used to relax blood vessels and it was adapted for this purpose almost twenty years ago. It rarely causes any pain although it has a slightly higher risk of causing priapism (an unnaturally long and painful erection which should be treated as an emergency to avoid damage to the penis) because it remains active in the body for a longer period of time than Alprostadil. It may also be slightly more likely to cause scarring if you hit the same injection point too often. You should not use this medication if you are drinking too much caffeine, alcohol or taking any other recreational drugs. Heavy smokers should also take care. You also cannot mix this medication with:

 

1.the barbiturates used for inducing sleep or treating seizures;

2.medicines such as temazepam or diazepam for sleeping or anxiety problems;

3.medicines to control Parkinson's disease; or

4.some narcotic pain killers such as morphine or tramadol.

The third drug is also a vasodilator: phentolamine sold as Regitine or Rogitine. It is rarely used on its own but usually in combination with one of the other two medications mentioned above.

 

Neither of the latter two medications have been approved by the FDA for this purpose — all this means is that the manufacturers have not gone through the expensive process of getting approval. But off-label use under medical supervision is quite common. So if either you or your partner are prepared to learn how to give the injections, this is a good system, available to use whenever you want with no real preparations required. Once givenScience Articles, they produce erections that are close to the body's own spontaneous erections and allow you to have an orgasm and an ejaculation. The erections last for between thirty minutes and two hours which is normally long enough for sexual intercourse to be satisfying. This is a cost-effective alternative to the more expensive and invasive surgical option. The only drawback is that the use of the injections is usually limited to three or four times per week to reduce the risk of scarring to your penis.

 

Source: Free Articles from ArticlesFactory.com

Keegan Segal is a writer for ManOfPeople . Read more  details on the subject of this article here: http://blog.manofpeople.com/archives/47


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Erectile dysfunction

Erectile dysfunction (ED) affects the lives of many middle-aged men and their partners. The term erectile dysfunction covers a range of disorders, but usually refers to the inability to obtain an adequate erection for satisfactory sexual activity. Although erectile dysfunction, formerly called impotence, is more common in men older than 65, it can occur at any age. An occasional episode of erectile dysfunction happens to most men and is normal. As men age, it's also normal to experience changes in erectile function. Erections may take longer to develop, may not be as rigid or may require more direct stimulation to be achieved. Men may also notice that orgasms are less intense, the volume of ejaculate is reduced and recovery time increases between erections. Erectile dysfunction may also be a sign of a physical or emotional problem that requires treatment.

Erectile dysfunction was once a taboo subject, but more men are seeking help. Doctors are gaining a better understanding of what causes erectile dysfunction and are finding new and better treatments.

This Website discusses all about erectile dysfunction, physiology of the normal erection and the pathophysiology, and treatment of ED.

What is Erectile Dysfunction?

Erectile dysfunction or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. There are various underlying causes, such as diabetes, many of which are medically reversible.

The causes may be physiological or psychological. Psychological impotence can often be helped by almost anything that the patient believes in; there is a very strong placebo effect.

Due to its embarrassing nature and the shame felt by sufferers, the subject was taboo for a long time, and is the subject of many urban legends. Folk remedies have long been advocated, with some being advertised widely since the 1930s. The introduction of perhaps the first pharmacologically effective remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by the news-worthiness of stories about it and heavy advertising.

The Latin term impotentia coeundi describes simple inability to insert the penis into the vagina. It is now mostly replaced by more precise terms.

Signs and symptoms:

Erectile dysfunction is characterized by the inability to maintain erection. Normal erections during sleep and in the early morning suggest a psychogenic cause, while loss of these erections may signify underlying disease, often cardiovascular in origin. Other things leading to erectile dysfunction are diabetes mellitus (causing neuropathy) or hypogonadism (decreased testosterone levels due to disease affecting the testicles or the pituitary gland).

Here are some causes of Erectile Dysfunction:

* Arousal: The first step is sexual arousal, which men obtain from the senses of sight, touch, hearing and smell, and from thoughts.

* Nervous system response: The brain communicates the sexual excitation to the body's nervous system, which activates increased blood flow to the penis.

* Blood vessel response:. A relaxing action occurs in the blood vessels that supply the penis, allowing more blood to flow into the shafts that produce the erection.

Physiology of normal erections:

Penile erections involve an integration of complex physiologic processes involving the CNS, peripheral nervous system, and hormonal and vascular systems. Any abnormality involving these systems, whether from medication or disease, has a significant impact on the ability to develop and sustain an erection, ejaculate, and experience orgasm. Tumescence, the vascular filling of the cavernous bodies, relies on neural and hormonal mechanisms operating at various levels of the neural axis. This is unique among visceral functions because it requires central neurological input.

Andersson et al summarized some of the information related to the pathways involved in erectile function. The degree of contraction of corpus cavernosal smooth muscle determines the functional state of the penis. The balance between contraction and relaxation is controlled by central and peripheral factors that involve many transmitters and transmitter systems. At the cellular level, smooth muscle relaxation occurs following the release of acetylcholine from the parasympathetic nerves.

Pathophysiology of erectile dysfunction:

Erectile Dysfunction is essentially a vascular disease. It is often associated with other vascular diseases and conditions such as diabetes, hypertension, and coronary artery disease. Other conditions associated with Erectile Dysfunction include neurologic disorders, endocrinopathies, benign prostatic hyperplasia, and depression. Conditions associated with reduced nerve and endothelium function, such as aging, hypertension, smoking, hypercholesterolemia, and diabetes, alter the balance between contraction and relaxation factors. These conditions cause circulatory and structural changes in penile tissues, resulting in arterial insufficiency and defective smooth muscle relaxation. In some patients, sexual dysfunction may be the presenting symptom of these disorders.

Treatment:

Sildenafil Citrate is the way to treat Erectile Dysfunction. Generic Viagra contains sildenafil citrate and contains same ingredients like branded drug.

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